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1 NNMT produces 1-methylnicotinamide (MNA) by transferring a methyl group to nicotinamide, which shapes important biochemical systems, such as: 1 Cellular methylation and stress responses Metabolic pathways NAD+ metabolism and cellular energy NNMT uses up nicotinamide, and high enzyme activity can reduce the amount left for the NAD+ salvage pathway, which recycles nicotinamide into fresh NAD+